Part 1 Science Notes

Anatomy + Surgical Anatomy

• Pelvic and Perineal Anatomy

  **Gynaecoid** (50%): round inlet, most favourable for vaginal delivery

• Uterine and Adnexal Anatomy

  Pear-shaped muscular organ, ~8cm long, ~5cm wide, ~2.5cm thick (non-pregnant)

Biochemistry

• Biochemistry for MRCOG Part 1

  All steroid hormones derive from cholesterol. The rate-limiting step is

Biophysics

• Biophysics and Imaging for MRCOG Part 1

  Diagnostic ultrasound uses frequencies of roughly **2–10 MHz**, generated by

Data Interpretation

• Data Interpretation for MRCOG Part 1

  A 95% confidence interval is the range within which the true population value

Embryology

• Embryology and Fetal Development

  | Stage | Timing | Key Events |

Endocrinology

• Reproductive Endocrinology

  Cholesterol → Pregnenolone → (two pathways)

Genetics, Immunology

• Genetics and Immunology for MRCOG Part 1

  | Pattern | Recognition | Obstetric examples |

Microbiology

• Microbiology and Infections in Obstetrics and Gynaecology

  | Infection | Organism | Key Fetal Effects | Diagnosis | Prevention/Treatment |

Pathology

• Gynaecological Pathology

  CIN 1: mild dysplasia, lower 1/3 of epithelium; most regress spontaneously (60%)

Pharmacology

• Pharmacology in Obstetrics and Gynaecology

  | Drug | Effect | Critical Period |

Physiology

• Maternal Physiological Changes in Pregnancy

  **Cardiac output**: increases 30-50% by 28-32 weeks (peaks mid-third trimester); due to increased stroke volume (early pregnancy) and heart rate (+15-20 bpm)

• Reproductive Physiology: The Menstrual Cycle

  **Hypothalamus**: secretes GnRH in a pulsatile fashion from the arcuate nucleus

Statistics & Epidemiology

• Statistics and Epidemiology for MRCOG

  | Measure | Formula | Interpretation |

MRCOG AI is an independent educational tool. It is not affiliated with, endorsed by, or connected to the Royal College of Obstetricians and Gynaecologists (RCOG).