Our blueprint estimate puts 15–20 of the 200 questions in pathology, about 8.8% of the paper, spread across both papers. It is our estimate, not a figure published by the RCOG. One of the heaviest-weighted areas on the paper.
Estimated questions
15–20
of 200
Syllabus topics
9
in our syllabus map
Domain
illness
3 other areas
How pathology is examined
Pathology in this exam is gynaecological pathology: the lesions of the cervix, endometrium, ovary and trophoblast, how they are classified, and how classification drives management.
What pathology covers
The 9 syllabus topics we map to Pathology for Part 1.
Cervical pathology (CIN, cervical cancer)
Endometrial pathology (hyperplasia, cancer)
Ovarian pathology (cysts, tumours, cancer)
Gestational trophoblastic disease
Placental pathology
Inflammation and wound healing
Thrombosis and embolism
Pre-eclampsia pathophysiology
Ectopic pregnancy pathology
High-yield pathology topics
Cervical disease and screening
High-risk HPV types account for most cervical cancer, while the low-risk types cause warts. Know the grading of intraepithelial neoplasia and how the screening programme triages results.
Management is organised around whether atypia is present. Oestrogen-dependent endometrioid cancer is the commonest type and carries a better prognosis than the non-endometrioid types.
Classify tumours by cell of origin and pair each with its marker. A granulosa cell tumour secretes oestrogen, which links it to endometrial hyperplasia.
Complete and partial moles differ in genetics, tissue and malignant potential, and choriocarcinoma is highly chemosensitive. Lichen sclerosus carries a small risk of vulval cancer, which is why it needs follow-up.
Assigning the wrong HPV types to cancer and to warts.
Overlooking a hormone-secreting tumour as the explanation for endometrial change.
Treating a mole as a single entity rather than complete or partial.
How to revise pathology
Organise by organ and by question: what is the lesion, how is it graded, what is the marker or screening test, and what is done about it. Pair each pathological classification with the management decision that follows from it, so the pathology is never revised in isolation. Revisit the trophoblastic and ovarian classifications often, since they are the easiest to blur.
Where pathology fits in Part 1
Part 1 is 200 single best answer questions across two papers with no negative marking, so an informed guess always beats a blank. Pathology is a high-yield area in our blueprint estimate. It maps onto the gynaecological oncology and early pregnancy modules of Part 2, where management questions rest on the same classifications.
Practise pathology questions
Every question is original and written from published RCOG and NICE guidance, and every explanation cites the guideline it came from. Free: 5 days full access, then 50 questions. No card.
MRCOG AI is an independent educational tool. It is not affiliated with, endorsed by, or connected to the Royal College of Obstetricians and Gynaecologists (RCOG).